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Obesity, defined as a body mass index (BMI) of 30, is a major public health issue with significant economic and societal impacts

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In the CANVAS study, treatment with canagliflozin was associated with an increased risk of amputations (primarily of the toe or metatarsals) and fractures.50 Fractures were more common in the limbs

Jamy Ard, The Obesity Society Past President "The TRIUMPH-4 topline results describing the efficacy of retatrutide in adults with obesity and knee osteoarthritis broke yet another barrier in the arms race of obesity medication therapies in development