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The guidance outlines both routine and additional risk minimisation activities (RMA).These measures are designed to improve awareness of important safety risks and reduce the likelihood of adverse outcomes
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Dosages are patient-specific but generally fall within a well-established therapeutic window
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinsons disease
Most patients start at 300 mcg/day and titrate toward 500 mcg/day
