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Data availability All data in this study is available from NHANES database (www.cdc.gov/nchs/nhanes)

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Secondary objectives include evaluating the effects of tirzepatide on weight, cardiac structure, and function

Muscle burns significantly more calories at rest than fat tissue, so protecting muscle mass partially offsets the metabolic slowdown that typically accompanies caloric restriction

Presented for research literature review only Salinas AE et al

Genetic redundancy within the pathway Given the genetic complexity of the pathway (Table 1), gene-specific Arabidopsis mutants have been very useful in defining the importance of the different isoforms