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Assay Drug Dev

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Oral B12 cannot get into the bloodstream in normal doses

However, to some extent, reasonable binding is still possible as long as the substrate is stabilized by His243 ( via -interaction of the aromatic ring) and the 1 st activity controller Asn240 (Fig

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Rats were administered either 5% PGN ( 10,000 Da .) in their drinking water or 5% d-CGN (PGN 40,000 Da