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With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
Conclusion This review has outlined the clinical rationale for combining pharmacological therapy, particularly GLP-1 RAs like semaglutide, with personalised dietary strategies in the treatment of obesity
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