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This intense inflammation is associated with damaging systemic events like oxidative stress, dysregulation of iron homeostasis, hypercoagulability and thrombus formation, acute respiratory distress syndrome, uncontrolled inflammation and organ failure (251257) (Figure 8)

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Typical genes, such as OCTN2 (encoded by SLC22A5) and /or BBD (encoded by BBOX1), regulated by PPAR play regulatory roles in the cellular fatty acid uptake, fatty acid activation, intracellular fatty acid transport, and -oxidation of mitochondrial and peroxisomal fatty acids (84)