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Based on preclinical data demonstrating substantial MPNST shrinkage in mice treated with a combination of MEK and mTOR inhibitors, SARC031 is a trial of the MEK inhibitor selumetinib in combination with the mTOR inhibitor sirolimus for patients with unresectable or metastatic MPNST
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Switching was defined as a change to a different GLP-1 between consecutive months (e.g., January to February 2025)
This gap helps prevent an overlap of the medications, which could lead to severe gastrointestinal side effects
Clinical trials showed average weight loss of about 18% of starting body weight over 72 weeks
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