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doi:10.1111/j.1468-1293.2011.00975.x

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45 Liver cytochrome P450 (CYP450) enzymes regulate the biotransformation of targeted agents (e.g., imatinib, erlotinib), and polymorphisms in these enzymes can result in therapeutic failure or toxicity

This is really alarming, said Rita Jew, a pharmacist and president of the Institute for Safe Medication Practices, in an interview ahead of the meeting