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They stimulate the pituitary gland to produce and release its own GH in a pulsatile, physiologic pattern

Functionally, GIP receptor activation improves intracellular Ca 2+ concentration, glucagon secretion, and cell depolarization by increasing cAMP/PKA signaling pathways [75, 76]

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Options include: Walking, starting with whatever distance feels comfortable Swimming or water-based exercise, where buoyancy reduces joint loading Cycling (stationary or outdoor), which keeps joints moving without heavy impact Gentle yoga or tai chi for flexibility and balance A systematic review of aquatic exercise for OA found it was effective for reducing pain, improving joint function, and improving quality of life

If TSH is suppressed, a radionuclide uptake scan may be considered