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Phentermine, a stimulant medication approved since 1959, works by increasing norepinephrine release to suppress appetite, while Wegovy (semaglutide) activates GLP-1 receptors to slow stomach emptying and promote satiety
Retatrutide targets three receptors GLP-1, GIP, and glucagon which is why clinics and influencers slapped the name GLP-3 on it
Focus on leafy greens, colorful vegetables, and lean proteins, which provide nutrients without the risk of an acute drug-herb interaction
Combined Protocol Example The following represents a typical 16-week protocol for someone starting both compounds: Tirzepatide: Weekly injection, following standard escalation from 2.5mg to 10mg over 16 weeks HGH: 2 IU upon waking (fasted) daily for weeks 1-4, increasing to 3 IU daily weeks 5-16 Cycle Length: 16-24 weeks, followed by 4-8 week break from HGH (Tirzepatide can continue) Monitoring: Bloodwork at baseline, week 8, and week 16 minimum This conservative approach allows proper adaptation to both compounds while providing meaningful body composition results
We see so many patients in practice coming in on peptides they heard about from social media, at the gym, or got from a wellness center. The enthusiasm is understandable: the biology is interesting, and the regenerative mechanisms aren't implausible
If topiramate must be used, consider reducing the use of other CNS-active medications that increase the risk of falls and fractures and implement strategies to reduce fall risk
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