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To account for multiple testing, a Bonferroni correction was applied

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One of them was called exendin-4 and it bore a striking similarity structurally and functionally to a human protein, called glucagon like peptide-1 (or GLP-1)

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the extracellular domain of each receptor binds the C-terminal half of the ligand, and the N-terminal half inserts into the transmembrane bundle to trigger activation