Infect cards have seen a ton of play in various formats, mostly due to how Infect interacts with various creature pump effects
The two decks we played with at the UKGE 2023 demo were pared-down versions of the Sleeping Beauty/Simba and Mickey Mouse/Moana decks that will be sold as part of the starter sets at Disney Lorcanas launch this summer
Binding the Old Gods Binding the Old Gods is a pretty comprehensive form of removal
It gives you a bit of a safety net against attacks if people want to draw their cards, but that's not enough of a gameplan on its own, so Doctor #2 really needs help from its companion to justify a spot in the command zone
Many older cards that still have a presence in Legacy, Commander, and Vintage may come with shroud attached - and it can be very useful to have if you know what to do with it
I had liked Progenitor Mimic, Howling Mine, and Swan Song as long-term holds, but theyre much worse off now